1. What is the P2X7 Receptor? The Purinergic receptor P2X7 (P2X7) is an ionotropic purinergic receptor activated by adenosine triphosphate (ATP). It regulates the influx of calcium (Ca²⁺) and sodium (Na⁺) and the efflux of… A New Therapeutic Mechanism for Chronic Kidney Disease (CKD) Discovered: The Role of Purinergic Receptor P2X7